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Yale Triple Negative Breast Cancer Cohort

ABSTRACT: Triple negative breast cancer (TNBC) is characterized by high proliferation, poor differentiation and a poor prognosis due to high rates of recurrence. Despite lower overall incidence African American (AA) patients suffer from higher breast cancer mortality in part due to the higher proportion of TNBC cases among AA patients compared to European Americans (EA). It was recently shown that the clinical heterogeneity of TNBC is reflected by distinct transcriptional programs with distinct drug response profiles in preclinical models. In this study, we used gene expression profiling and immunohistochemistry to eluicidate potential differences between TNBC tumors of EA and AA patients on a molecular level.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46581 | GEO | 2013/08/15

SECONDARY ACCESSION(S): PRJNA201430

REPOSITORIES: GEO

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Yale Triple Negative Breast Cancer Cohort

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