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Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB

ABSTRACT: Comparison of transcriptional profiles of human umbilical vein endothelial cells (HUVECs) expressing wild-type vs. VM-causative mutant forms of TIE2/TEK. The effects of the most common Venous Malformation-causative mutations in the endothelial cell tyrosine kinase receptor: R849W and L914F, were tested. 743 genes were differentially expressed across the four groups. The 80 genes distinguishing between L914F and wild-type TIE2-expressing HUVECs were analyzed in greater detail.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46684 | GEO | 2013/06/04

SECONDARY ACCESSION(S): PRJNA201508

REPOSITORIES: GEO

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Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB

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