Transcriptomics

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Genome-wide expression analysis of the highly metastatic lung cancer cell line NCI-H460-LNM35


ABSTRACT: Widespread metastasis is the major cause of human lung cancer-related deaths, but there is much to be elucidated about underlying mechanism. Based on the genome-wide expression analysis of the highly metastatic lung cancer cell line NCI-H460-LNM35 (LNM35), we identified a cancer metastasis signature composed of 45 genes with previously uncharacterized features but well-known associations with human cancers including CXCL1, IER3, PTTG1, DAD1, METAP2, E-cadherin and galectin 3. In addition, the 45-gene metastasis signature gene set was significantly associated with a subset of primary tumors with poor prognosis not only in the lung but also the breast. Keywords: cell-line morphologic comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE4705 | GEO | 2007/01/20

SECONDARY ACCESSION(S): PRJNA96757

REPOSITORIES: GEO

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