Transcriptomics

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Effect of hypoxia on Mycobacterium tuberculosis-host phagocyte interactions


ABSTRACT: Mtb appears to have developed specialized biomolecular infrastructure to survive and persist within granulomas, where it is subjected to a diverse set of stress conditions. One of these stress conditions is hypoxia. We hypothesized that host cell response is radically altered with hypoxia stressed Mtb and designed in-vitro experiments to study this phenomenon. Hypoxia-stressed as well as aerobically grown Mtb were used to infect rhesus macaque bone marrow derived macrophages (Rh-BMDMs) and the host global transcriptional response compared.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE47163 | GEO | 2013/05/22

SECONDARY ACCESSION(S): PRJNA204939

REPOSITORIES: GEO

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