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MicroRNA expression array for 1833 cells expressing RKIP vs. control

ABSTRACT: RKIP has been implicated in suppression of breast tumor metastasis. Identification of microRNAs regulated by RKIP helps us to understand how RKIP suppresses tumor metastasis via its downstream target mircoRNAs and genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE47366 | GEO | 2014/07/01

SECONDARY ACCESSION(S): PRJNA205364

REPOSITORIES: GEO

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MicroRNA expression array for 1833 cells expressing RKIP vs. control

Project description:RKIP has been implicated in suppression of breast tumor metastasis. Identification of microRNAs regulated by RKIP helps us to understand how RKIP suppresses tumor metastasis via its downstream target mircoRNAs and genes. Total RNA was extracted from 1833 cells expressing RKIP or control, respectively. Exiqon miRCURY LNA array v.11.0. was performed to identify the microRNAs regulated by RKIP.

2014-07-01 | E-GEOD-47366 | biostudies-arrayexpress

Gene expression data from 1833 cells expressing RKIP vs control

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Gene expression data from 1833 cells expressing RKIP vs control

Project description:RKIP regulates human breast tumor metastasis. We use gene expression array analysis to identify genes regulated by RKIP in human breast cancer cells. Total RNAs were extracted from 1833 cells expressing mutant RKIP (S153E-RKIP, a more potent Raf-1 inhibitor) and vector control. Affymetrix GeneChip hgu133plus2.0 Arrays were performed to detail the gene expression and identify the genes regulated by RKIP in human breast cancer cells.

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MicroRNA expression array of 1833 cells: control vs. HMGA2 shRNA

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Gene expression data from BM1 (1833) tumors that are wild type or overexpressing RKIP in a xenograft mouse model

Project description:RKIP is a metastasis suppressor that is lost or silenced in most metastatic cancers. Here we reintroduce RKIP exogenously into BM1 cells (bone-tropic derivative of MDA-MB-231 cells, also known as 1833) that lack RKIP expression, in order to study transcriptomic changes that lead to metastasis in vivo and identify actionable targets to be used in anti-metastatic treatment strategies.

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1833 cells expressing RKIP vs control

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-07-01 | GSE47379 | GEO

Gene expression data from 1833 cells expressing RKIP vs control

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