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Analysis of change in circulating microRNAs in mice during breast tumor development

ABSTRACT: The aim of this study was to analyse alterations in circulating microRNA expression during breast tumour progression in a murine model, and to apply significantly altered miRNAs to patient samples to identify novel circulating microRNA markers or tumour progression. Athymic nude mice (n=10) received an injection of 2 x 105 MDA-MB-231 cells. Tumour volume was monitored weekly and blood sampling performed at weeks 1 and 6 following tumour induction. A microRNA array was performed comparing circulating 384 microRNAs in animals with early (week 1, n=5) versus late (week 6, n=5) disease.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE47455 | GEO | 2013/09/01

SECONDARY ACCESSION(S): PRJNA205636

REPOSITORIES: GEO

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Analysis of change in circulating microRNAs in mice during breast tumor development

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