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A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation

ABSTRACT: A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. We report the identification and biologic characterization of an LPS-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (CyP). Keywords: different ligands

ORGANISM(S): Homo sapiens

PROVIDER: GSE4748 | GEO | 2006/07/27

SECONDARY ACCESSION(S): PRJNA95695

REPOSITORIES: GEO

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Transcription profiling of human dendritic monocytes treated with LPS (lipopolysaccharide) or CyP (Cyanobacterial Product) reveals cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression

Project description:A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. We report the identification and biologic characterization of an LPS-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (CyP).

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