Transcriptomics

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HOTAIR reprograms gene expression profiling in esophageal squamous cell carcinoma (ESCC) KYSE180 cells


ABSTRACT: To investigate the functional role of HOTAIR in esophageal squanmous cell carcinoma (ESCC) cells, RNAi-mediated knockdown of HOTAIR and overexpression of HOTAIR were carried out using KYSE180 cells. Gene expression microarray analysis revealed that a number of reported HOTAIR target genes were regulated by HOTAIR. Moreover, gene ontology analysis revealed enrichment of genes closely related to tumorigenesis, such as cell migration, regulation of cell cycles.

ORGANISM(S): Homo sapiens

PROVIDER: GSE47638 | GEO | 2013/06/05

SECONDARY ACCESSION(S): PRJNA206999

REPOSITORIES: GEO

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