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Decline of Nucleotide Excision Repair Capacity in Aged Caenorhabditis elegans

ABSTRACT: We used gene expression profiling to address several specific questions that arose in a study of repair of ultraviolet C radiation in C elegans, as well as to generate hypotheses regarding the possible mechanism(s) of decreased DNA repair observed in old adults in that study. This analysis was performed in order to analyze gene expression in the strain (JK1107) and experimental conditions that we used for our DNA repair studies. The supplementary file GSE4766_Resolver_all_data.txt includes Resolver generated fold-changes and p values based on ratios built in Rosetta Resolver as described in the Rosetta Biosoftware Technical Note (Lee Weng, 2004), Data processing and analysis methods in the Rosetta Resolver system (http://www.rosettabio.com/tech/default.htm). Keywords: C elegans, glp-1, age, nucleotide excision repair, ultraviolet radiation, DNA damage

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE4766 | GEO | 2007/05/16

SECONDARY ACCESSION(S): PRJNA95645

REPOSITORIES: GEO

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