Transcriptome analysis of Germinal Center and naïve B cells from miR-217TG and control mice by RNAseq
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ABSTRACT: microRNAs (miRNAs) regulate virtually all biological processes, but little is known of their role in germinal center (GC) B cells. While the GC reaction is crucial to ensure a competent immune response, GC B cells are also the origin of most human lymphomas. Here we report that miR-217 is specifically upregulated in GC B cells. Gain- and loss-of-function mouse models reveal that miR-217 functions as a positive modulator of the GC response through the regulation of a DNA repair gene network. Moreover, we show that miR-217 overexpression promotes mature B cell lymphomagenesis. Therefore miR-217 provides a novel molecular link between the normal GC response and B cell transformation
ORGANISM(S): Mus musculus
PROVIDER: GSE47877 | GEO | 2014/07/15
SECONDARY ACCESSION(S): PRJNA208231
REPOSITORIES: GEO
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