Transcriptomic profiling of Ewing's sarcoma cell lines after knockdown of TRIP6
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ABSTRACT: This study aimed to explore the role of the Zyxin-related protein TRIP6 (thyroid receptor interacting protein 6) in Ewing's sarcoma (ES). By interrogation of published miccroarray data, we observed that of all seven Zyxin-proteins only TRIP6 is highly overexpressed in ES compared to normal tissues. RNA interference experiments and subsequent microarray and gene-set enrichment analyses indicated that TRIP6 expression is associated wth a pro-proliferative and pro-invasive transcriptional signature. Consistently, functional assays demonstrated that TRIP6 promotes migration, invasion, long-term proliferation and clonogencity of ES cells.
ORGANISM(S): Homo sapiens
PROVIDER: GSE48010 | GEO | 2014/01/01
SECONDARY ACCESSION(S): PRJNA208667
REPOSITORIES: GEO
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