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Expression data from tumoral thymocytes and DP thymocytes expressing an activated form of b-catenin in mouse T cells

ABSTRACT: To assess the importance of the Wnt pathway during T cell develoment, we generated a mouse line (R26-βcat) in which high levels of active β-catenin are maintained throughout T cell development. Young R26-βcat mice (6-week-old) show a differentiation block at the CD4+CD8+ DP stage. All R26-βcat mice develop T cell leukemias with a DP phenotype at 5-6 months of age. To identify the molecular pathways involved in tumor development, we profiled the global gene expression of transformed and pre-transformed DP cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE48203 | GEO | 2013/06/21

SECONDARY ACCESSION(S): PRJNA209194

REPOSITORIES: GEO

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Expression data from tumoral thymocytes and DP thymocytes expressing an activated form of b-catenin in mouse T cells

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