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PU.1 and Spi-B oppose transformation of pre-B cells through activation of key genes involved in B cell receptor signaling

ABSTRACT: Deletion of genes encoding the E26 transformation-specific (ETS) transcription factors, PU.1 and Spi-B, in B cells (CD19-CreDPB mice) leads to acute lymphoblastic leukemia at 100% incidence and with a median survival of 21 weeks. To identify pathways of leukemic transformation, we compared gene expression in leukemia cells from CD19-CreDPB mice (CD19-CreDPB B220- B-ALL) with B cells from Spi-B knockout (Control DB) or B cells from CD19-CreDPB mice (CD19-CreDPB B220+ B cell)

ORGANISM(S): Mus musculus

PROVIDER: GSE48891 | GEO | 2014/11/12

SECONDARY ACCESSION(S): PRJNA212137

REPOSITORIES: GEO

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