Transcriptomics

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Gene expression in aortic roots of Apoe KO mice with Nod1 stimulation


ABSTRACT: To explore the mechanisms underlying progression of atherosclerosis provoked by Nod1 ligand stimulation, we performed microarray gene expression profiling of aortic roots of 6- and 9-week-old Apoe KO mice with or without oral FK565 administration. A gene ontology analysis of the genes up-regulated in FK565-administrated group at both time points showed that a number of biological process terms were associated with immune response. Among chemokine/cytokine genes, we observed that only 3 genes such as Ccl5, Ccl8 and Cxcl16 elevated more than 2-fold in response to oral administration of FK565 at both time points.

ORGANISM(S): Mus musculus

PROVIDER: GSE48947 | GEO | 2014/11/06

SECONDARY ACCESSION(S): PRJNA212381

REPOSITORIES: GEO

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