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Profiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

ABSTRACT: Analysis of methylomic alternations related with alcohol use disorders (AUD). The hypothesis is that chronic alcohol consumption might alter genome-wide DNA methylation patterns. The results suggest that differential DNA methylation might be invovled in neuradaptations to alcohol.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49393 | GEO | 2013/11/06

SECONDARY ACCESSION(S): PRJNA213875

REPOSITORIES: GEO

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Profiling Methylomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

Project description:Analysis of methylomic alternations related with alcohol use disorders (AUD). The hypothesis is that chronic alcohol consumption might alter genome-wide DNA methylation patterns. The results suggest that differential DNA methylation might be invovled in neuradaptations to alcohol. Genomic DNA was extraced from postmortem prefrontal cortex tissues of 23 AUD cases and 23 matched controls. Both AUD cases and matched controls are assessed with DSM-IV

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Profiling Transcriptomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders

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