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MicroRNA Dysregulation in Human Prostate Cancer Cell Model (M12 and P69)

ABSTRACT: An isogenic prostate cancer cell model was used to profile miRNA changes that contribute to the tumorigenic state of prostate cancer. P69 cells are an SV40 large T antigen immortalized cell line that is poorly tumorigenic and non-metastatic. The M12 derivative was derived from an in vivo selection process using nude, athymic mice. Immortalized cells were cultured and used to extract RNA and probed against the human miRNA panel from Exiqon. There were a total of 186 miRNAs that were at least two fold differentially regulated .

ORGANISM(S): Homo sapiens

PROVIDER: GSE49520 | GEO | 2013/08/15

SECONDARY ACCESSION(S): PRJNA214099

REPOSITORIES: GEO

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