Transcriptomics

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IL-2-dependent gene expression by human regulatory T cells


ABSTRACT: This study determined the genes that are differetially expressed when regulatory T cells were stimulated in vitro with IL-2 388 Affymetrix targets were found to be up or down regulated in human regulatory T cells by IL-2 by two-fold or more. Gene enrichment analyss identified that IL-2 functions to regulate gene expression for mRNAs important for immune system processes, cell growth, cell death, inflammatory response, cell migration, and the Jak/Stat pathway, among others. A subset of these differentially expressed genes were distinctively expressed between individual subjects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49817 | GEO | 2015/07/09

SECONDARY ACCESSION(S): PRJNA214999

REPOSITORIES: GEO

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