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YAP conveys an invasive phenotype to clear cell renal cell carcinoma cell lines via endothelin-2

ABSTRACT: To determine the biological mechanisms underlying the oncogenic properties of YAP in ccRCC the human ccRCC cell line MZ1774 was transduced with lentivirus containing a shRNA-cassette targeting YAP-mRNA. Expression profiles of MZ1774 YAP knockdown cells were compared to mock-transduced control cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE50053 | GEO | 2014/12/23

SECONDARY ACCESSION(S): PRJNA215872

REPOSITORIES: GEO

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YAP conveys an invasive phenotype to clear cell renal cell carcinoma cell lines via endothelin-2

Project description:To determine the biological mechanisms underlying the oncogenic properties of YAP in ccRCC the human ccRCC cell line MZ1774 was transduced with lentivirus containing a shRNA-cassette targeting YAP-mRNA. Expression profiles of MZ1774 YAP knockdown cells were compared to mock-transduced control cells. Total RNA from MZ1774 cells stably expressing shRNA directed against YAP compared to mock-transduced MZ1174 cells

2014-12-23 | E-GEOD-50053 | biostudies-arrayexpress

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Genome-wide analysis of differentially expressed genes and splicing isoforms in clear cell Renal Cell Carcinoma

Project description:In this study we performed a genome wide analysis of the entire complement of mRNAs in clear cell renal cell carcinomas (ccRCC) by means of the Affymetrix Exon Array platform. The analyses were performed both at gene and exon level. Under our parameters over 2,000 genes resulted differentially expressed, and about 250 genes resulted alternative spliced showing differential inclusion of specific cassette exons comparing tumor and non tumoral tissues.

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Deregulated Expression of the 14q32 miRNA Cluster in Clear Cell Renal Cell Carcinomas

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2023-05-10 | PXD036428 | Pride

MicroRNA expression of clear cell papillary renal cell carcinoma

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Clear cell renal cell carcinoma (ccRCC) samples

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2013-05-25 | E-GEOD-47352 | biostudies-arrayexpress

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LncRNA from metastatic clear cell renal cell carcinoma (ccRCC) compared with non-metastatic clear cell renal carcinoma

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2017-08-17 | GSE88948 | GEO

Integrative genomic analysis of sporadic clear cell Renal Cell Carcinoma

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