Comparative Transcriptional Profiling of Human Merkel cells and Merkel Cell Carcinoma
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ABSTRACT: Merkel cell carcinoma is supposed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly known events. A transcriptional profiling with cDNA microarrays was performed on cells from MCPyV(+) Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and downregulated genes. The extensive list of genes identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.
ORGANISM(S): Homo sapiens
PROVIDER: GSE50434 | GEO | 2014/01/01
SECONDARY ACCESSION(S): PRJNA217485
REPOSITORIES: GEO
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