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Somatic copy number variation profiling in matched brain and extracranial metastases of melanoma

ABSTRACT: An improved understanding of the molecular pathogenesis of brain metastases, one of the most common and devastating complications of advanced melanoma, may identify and prioritize rational therapeutic approaches for this disease. In particular, the identification of molecular differences between brain and extracranial metastases would support the need for the development of organ-specific therapeutic approaches. Hotspot mutations, copy number variations (CNV), global mRNA expression patterns, and protein expression and activation, quantitatively analyzed by mass-array genotyping, molecular inversion probe arrays, microarrays and reverse phase protein array (RPPA) were evaluated in pairs of melanoma brain metastases and extracranial metastases from patients who had undergone surgical resection for both types of tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE50495 | GEO | 2014/05/08

SECONDARY ACCESSION(S): PRJNA217774

REPOSITORIES: GEO

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