Transcriptomics

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Expression data from testes of the mouse X-chromosome substitution strains


ABSTRACT: To investigate the evolutionary divergence of transcriptional regulation between the mouse subspecies, we performed transcriptome analysis by microarray on testes from the X-chromosome substitution strain, which carries different subspecies-derived X chromosome on the host subspecies genome. Transcription profiling showed that large-scale aberrations in gene expression were occurred on the introgressed X chromosome. This improper expression was restored by introducing chromosome 1 from the same donor strain as the X chromosome, suggesting that the genetic incompatibility between trans-acting regulatory gene(s) on chromosome 1 and X-linked downstream genes might be a cause of the misregulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE50687 | GEO | 2014/01/31

SECONDARY ACCESSION(S): PRJNA218528

REPOSITORIES: GEO

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