Transcriptomics

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Expression data from non-pigmented and pigmented mouse melanocytes


ABSTRACT: Immortalized, amelanotic melanocytes isolted from skin of Balb/c express enzymatically-inactive tyrosinase due to a homozygous point mutation (TGT->TCT) in tyrosinase gene, resulting in a lack of melanin . To serve as a control cell line, pigmentation was restored in these cells by correcting the point mutation using an RNA-DNA oligonucleotide (kingly gift from Dr. Alexeev Y. Vitali). We used microarray to detail the effect of tyrosinase mutation on gene expression in normal versus mutant melanocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE51073 | GEO | 2013/09/21

SECONDARY ACCESSION(S): PRJNA221110

REPOSITORIES: GEO

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