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M. tuberculosis H37Rv: mutant expressing foreign peptide SL3 Vs control H37Rv

ABSTRACT: Transcriptional profiling of M.tb H37Rv cells comparing control wild type H37Rv with H37Rv cells electroporated with constitutive expression plasmid pVV16 expressing ESAT-6 binding peptide SL3. The expression of SL3 makes H37Rv less virulent during ex vivo and BalB/c mice infections, sequesters ESAT-6 inside M.tb cells and cause severe defects in mycobacterial morphology. Goal was to determine the effects of SL3 expression on global H37Rv gene expression.

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE51085 | GEO | 2014/04/10

SECONDARY ACCESSION(S): PRJNA221145

REPOSITORIES: GEO

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M. tuberculosis H37Rv: mutant expressing foreign peptide SL3 Vs control H37Rv

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