MRNA profile of CD8 T cells from chronic HBV patients
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ABSTRACT: The low frequency of HBV-specific CD8+ T cells in the peripheral blood of CHB patients has limited studies of the mechanisms underlying HBV-induced T cell exhaustion. Similar to the expansion defect displayed in HBV-specific CD8+ T cells, TCR-induced proliferation of global CD8+ T cells is impaired in a fraction of chronic HBV (CHB) patients. Thus, examining the molecular regulation of global CD8+ T cell function in CHB patients may provide insight into the exhaustion of HBV-specific CD8+ T cells. We used microarrays to detail the global programme of gene expression of CD8 T cells from CHB patients who have not received anti-viral treatment.
ORGANISM(S): Homo sapiens
PROVIDER: GSE51489 | GEO | 2016/07/01
SECONDARY ACCESSION(S): PRJNA223293
REPOSITORIES: GEO
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