Therapy-induced PML nuclear body re-formation and p53 activation trigger acute promyelocytic leukaemia cure
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ABSTRACT: The therapy-induced PML/RARA catabolism elicits the loss of APL-initiating cell self-renewal through PML NB reformation and P53 activation. These results explain the curative activity of the RA/arsenic combination, the resistance to RA of PLZF/RARA-driven APLs and they raise the prospect that activation of this PML/P53 checkpoint might have therapeutic values in other malignancies.
ORGANISM(S): Mus musculus
PROVIDER: GSE51723 | GEO | 2014/01/11
SECONDARY ACCESSION(S): PRJNA224733
REPOSITORIES: GEO
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