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Genome-wide profiling of DNA methylation and expression identifies CIMP in myelodysplastic syndrome [Illumina]

ABSTRACT: To identify genes hypermethylated and transcriptionally downregulated, we have employed the Illumina Infinium HumanMethylation450 BeadChip and Agilent SurePrint G3 Human Gene Expression 8x60K. And we validated selected genes in cases and controls. eventually we estalished CIMP of MDS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE51758 | GEO | 2013/10/29

SECONDARY ACCESSION(S): PRJNA224961

REPOSITORIES: GEO

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Genome-wide profiling of DNA methylation and expression identifies CIMP in myelodysplastic syndrome [Illumina]

Project description:To identify genes hypermethylated and transcriptionally downregulated, we have employed the Illumina Infinium HumanMethylation450 BeadChip and Agilent SurePrint G3 Human Gene Expression 8x60K. And we validated selected genes in cases and controls. eventually we estalished CIMP of MDS. Bisulphite converted DNA from the 4 patients and 4 controls were hybridised to the Illumina Infinium 450k Human Methylation Beadchip

2013-10-29 | E-GEOD-51758 | biostudies-arrayexpress

Genome-wide profiling of DNA methylation and expression identifies CIMP in myelodysplastic syndrome [Agilent]

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Genome-wide profiling of DNA methylation and expression identifies CIMP in myelodysplastic syndrome [Agilent]

Project description:To identify genes hypermethylated and transcriptionally downregulated, we have employed the Illumina Infinium HumanMethylation450 BeadChip and Agilent SurePrint G3 Human Gene Expression 8x60K.And we validated selected genes in cases and controls. eventually we estalished CIMP of MDS. The gene expressions of four cases and four controls were measured.

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