A bioinformatics approach reveals novel mechanisms of the OVOL transcription factors in the regulation of epithelial-mesenchymal cell programming and cancer progression.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE51975 | GEO | 2014/03/20
SECONDARY ACCESSION(S): PRJNA225955
REPOSITORIES: GEO
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Project description:We find significant evidence of the OVOL, AP1, STAT1, STAT3, and NFKB1 TFs having important roles in MET. We prioritize known gene/drug targets for follow-up in the clinic, and show that the AP1/MYC TF pair is a strong candidate for intervention. Examination of the effects of OVOL1 and OVOL2 overexpression common to prostate cancer and breast cancer models.
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Project description:sJIA patients were recruited through the Stanford Pediatric Rheumatology Clinic. All sJIA study subjects met amended ILAR criteria for the diagnosis of SJIA. The study was approved by the Stanford Institutional Review Board.
2012-09-06 | GSE37388 | GEO
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