Genomics

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MiRNAs expression of soleus response to simulated microgravity


ABSTRACT: Identification of gravisensitive miRNAs expression in rat soleus muscle exposed to 7 and 14 days of Hindlimb suspension (HS) simulated microgravity. Microgravity causes muscle atrophy possibly due to muscle wasting overtake regeneration. Results provide insight into the molecular mechanisms regulating muscle atrophy. The expression of 23 out of 174 miRNAs was found to change at least 2-fold of 7 and/or 14 days of TS. By using real-time PCR assays, we verified the microarray data using some of the expected genes.

ORGANISM(S): synthetic construct Rattus norvegicus

PROVIDER: GSE52055 | GEO | 2013/11/05

SECONDARY ACCESSION(S): PRJNA226597

REPOSITORIES: GEO

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