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Biased gene expression in early honeybee larval development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Apis mellifera

PROVIDER: GSE52291 | GEO | 2013/11/13

SECONDARY ACCESSION(S): PRJNA227347

REPOSITORIES: GEO

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Biased gene expression in early honeybee larval development

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-13 | E-GEOD-52291 | biostudies-arrayexpress

Biased gene expression in early honeybee larval development.

Project description:BackgroundFemale larvae of the honeybee (Apis mellifera) develop into either queens or workers depending on nutrition. This nutritional stimulus triggers different developmental trajectories, resulting in adults that differ from each other in physiology, behaviour and life span.ResultsTo understand how these trajectories are established we have generated a comprehensive atlas of gene expression throughout larval development. We found substantial differences in gene expression between worker and queen-destined larvae at 6 hours after hatching. Some of these early changes in gene expression are maintained throughout larval development, indicating that caste-specific developmental trajectories are established much earlier than previously thought. Within our gene expression data we identified processes that potentially underlie caste differentiation. Queen-destined larvae have higher expression of genes involved in transcription, translation and protein folding early in development with a later switch to genes involved in energy generation. Using RNA interference, we were able to demonstrate that one of these genes, hexamerin 70b, has a role in caste differentiation. Both queen and worker developmental trajectories are associated with the expression of genes that have alternative splice variants, although only a single variant of a gene tends to be differentially expressed in a given caste.ConclusionsOur data, based on the biases in gene expression early in development together with published data, supports the idea that caste development in the honeybee consists of two phases; an initial biased phase of development, where larvae can still switch to the other caste by differential feeding, followed by commitment to a particular developmental trajectory.

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Queen and worker honeybee castes are defined by alternative chromatin states during larval development

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Biased gene expression in early honeybee larval development (microarray)

Project description:Female larvae of the honeybee (Apis mellifera) develop into either queens or workers depending on nutrition during larval development. This nutritional stimulus triggers different developmental trajectories, resulting in adults that differ in physiology, behaviour and life-span. To understand how these developmental trajectories are established we have undertaken a comprehensive analysis of differential gene expression throughout larval development. Gene expression of honeybee queen and worker larval samples was analysed at seven time points during larval development (6 hr, 12 hr, 36 hr, 60 hr, 84 hr, 108 hr and 132 hr)

2013-11-13 | E-GEOD-52288 | biostudies-arrayexpress

Biased gene expression in early honeybee larval development (sequencing)

2013-11-13 | E-GEOD-52289 | biostudies-arrayexpress

Biased gene expression in early honeybee larval development (sequencing)

2013-11-13 | GSE52289 | GEO

Biased gene expression in early honeybee larval development (microarray)

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Essential control of early B-cell development by Mef2 transcription factors

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