Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation
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ABSTRACT: Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. Microarray analysis revealed that a significant proportion of PGC-1alpha-dependent changes in gene expression overlapped with age-associated effects, and aging muscle and muscle lacking PGC-1alpha shared gene signatures of impaired electron transport chain activity and TGFbeta signalling.
ORGANISM(S): Mus musculus
PROVIDER: GSE52550 | GEO | 2013/12/05
SECONDARY ACCESSION(S): PRJNA229363
REPOSITORIES: GEO
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