Transcriptomics

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Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models


ABSTRACT: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial and sporadic Parkinson’s disease (PD). Here, we investigated in parallel gene and microRNA transcriptome profiles of three different LRRK2 mouse models. Striatal tissue was isolated from adult LRRK2 knockout mice, as well as mice expressinghuman LRRK2 wildtype (hLRRK2-WT) or PD-associated R1441G mutation (hLRRK2-R1441G).

ORGANISM(S): Mus musculus synthetic construct

PROVIDER: GSE52584 | GEO | 2013/11/22

SECONDARY ACCESSION(S): PRJNA229469

REPOSITORIES: GEO

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