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Genome-wide Profiling of Steroid Receptor Coactivator 2 in mouse liver

ABSTRACT: Steroid Receptor 2 (SRC-2) is a coactivator involved in hepatic metabolism. To better understand its temporal involvement in metabolism genome wide profiling was performed at 2 time ZT4 and ZT18 as well as in the SRC-2 knockout mouse.

ORGANISM(S): Mus musculus

PROVIDER: GSE53039 | GEO | 2014/11/10

SECONDARY ACCESSION(S): PRJNA230719

REPOSITORIES: GEO

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Steroid Receptor Coactivator-2 Regulated Transcriptome in Human Endometrial Stromal Cells

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Tissue- and Pathway-Specific Metabolomic Profiles of the Steroid Receptor Coactivator (SRC) family

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Project description:Using conditional knockout technology, we demonstrate that steroid receptor coactivator-2 (SRC-2) is essential for development of the receptive uterus for embryo implantation. Through bulk RNA-seq analysis, we reveal that endometrial SRC-2 is required for not only the induction of the expression of established genes associated with uterine receptivity but also for the expression of genes involved in endometrial epithelial changes that enable attachment and invasion of the embryo into the underlying stroma. Together, these RNA-seq results underscore the importance of SRC-2 as a transcriptional coregulator in the endometrium during the periimplantation period.

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