Transcriptomics

Dataset Information

0

HEXIM knockdown triggers apoptosis-induced proliferation and deregulates Hedgehog signaling


ABSTRACT: We address the function of HEXIM, an inhibitor of the general transcriptional elongation regulator P-TEFb which regulates the transcriptional status of many developmental genes, during Drosophila development. We showed that HEXIM knockdown mutants display organs development failure. In the wing disc, it induces apoptosis and affects Hh signaling. The continuous death of proliferative cells is compensated by apoptosis-induced cell proliferation, in a manner similar to that of differentiated cells, together with high levels of Hh and Ci. We completed this analysis with microarrays to characterize the molecular phenotype of HEXIM knockdown during eye differentiation.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE54590 | GEO | 2014/07/31

SECONDARY ACCESSION(S): PRJNA237103

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-07-31 | E-GEOD-54590 | biostudies-arrayexpress
2013-05-04 | GSE46601 | GEO
2013-05-04 | E-GEOD-46601 | biostudies-arrayexpress
| PRJNA237103 | ENA
2016-04-08 | GSE57431 | GEO
2016-04-08 | GSE57430 | GEO
2016-03-14 | E-GEOD-77042 | biostudies-arrayexpress
2024-01-31 | GSE203127 | GEO
2016-03-14 | GSE77042 | GEO
2020-06-07 | GSE151935 | GEO