Transcriptomics

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Identification of HIF1 and HIF2 target genes in human CB CD34+ cells


ABSTRACT: Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are involved. We identified transcriptome changes induced by hypoxia, constitutively active HIF1(P402/564) and HIF2(P405/531) in human cord blood CD34+ cells. Thus, we were able to identify common hypoxia-HIF1-HIF2 gene signatures, but we also identified specific target genes that were exclusively regulated by HIF1, HIF2 or hypoxia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE54662 | GEO | 2014/03/01

SECONDARY ACCESSION(S): PRJNA237310

REPOSITORIES: GEO

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