Transcriptomics

Dataset Information

0

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct


ABSTRACT: Macrophages adopt an alternatively activated phenotype (AAM) when activated by IL-4. While these AAMs can be derived from local proliferation of resident tissue macrophages or recruited inflammatory monocytes, it is not known whether these different AAMs are phenotypically and functionally distinct. Using microarray analysis of gene expression, we demonstrated that while both monocyte- and tissue-derived AAM expressed high levels of Arg1, Chi3l3 and Retnla, only monocyte-derived AAM upregulated Raldh2 and PD-L2. The distinction between monocyte- and tissue-derived macrophages can, therefore, be made using different phenotypic markers.

ORGANISM(S): Mus musculus

PROVIDER: GSE54679 | GEO | 2014/02/05

SECONDARY ACCESSION(S): PRJNA237341

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-02-05 | E-GEOD-54679 | biostudies-arrayexpress
2021-10-06 | GSE151654 | GEO
2021-10-06 | GSE151653 | GEO
2017-06-17 | GSE100105 | GEO
2010-07-19 | GSE20030 | GEO
2011-10-04 | E-GEOD-32621 | biostudies-arrayexpress
2003-07-16 | GSE477 | GEO
2008-06-13 | E-GEOD-477 | biostudies-arrayexpress
2010-07-19 | E-GEOD-20030 | biostudies-arrayexpress
2017-06-25 | GSE82158 | GEO