Transcriptomics

Dataset Information

0

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia


ABSTRACT: Many human cancers are dramatically accelerated in the setting of chronic inflammation. However the specific cellular and molecular elements mediating this effect remain largely unknown. Using a murine model of pancreatic intraepithelial neoplasia (PanIN), we found that KrasG12D induces expression of functional IL-17 receptors on PanIN cells, and stimulates infiltration of the pancreatic stroma by IL-17-producing immune cells. Both effects are augmented by chronic pancreatitis, resulting in functional in vivo changes in gene expression among PanIN epithelial cells. Forced IL-17 overexpression dramatically accelerates PanIN initiation and progression, while inhibition of IL-17 signaling using genetic or pharmacologic techniques effectively prevents PanIN formation. Together, these studies suggest that a hematopoietic-to-epithelial IL-17 signaling axis is a potent and requisite driver of PanIN formation.

ORGANISM(S): Mus musculus

PROVIDER: GSE54753 | GEO | 2016/02/03

SECONDARY ACCESSION(S): PRJNA237551

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-07-25 | E-GEOD-68090 | biostudies-arrayexpress
2016-07-25 | GSE68090 | GEO
2017-03-14 | GSE88997 | GEO
2024-06-26 | GSE269888 | GEO
2024-04-15 | GSE264054 | GEO
2013-06-20 | E-GEOD-47985 | biostudies-arrayexpress
2024-07-26 | GSE273209 | GEO
2013-06-20 | GSE47985 | GEO
2017-05-31 | GSE99438 | GEO
2018-09-12 | GSE119858 | GEO