Rbfox2 controls autoregulation in RNA binding protein networks
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ABSTRACT: We generated a global analysis of Rbfox2 splicing regulation combined with a highly specific, single nucleotide-resolution Rbfox2 RNA binding map. We found that Rbfox2 regulates the splicing and expression of many previously unknown targets, and particularly a number of RNA binding proteins (RBPs), by modulating alternative splicing coupled-NMD. Based on our observations of RBP-Rbfox2 co-regulation with a polarity predicted by Rbfox2 binding, we propose a model whereby Rbfox2 tunes autoregulatory splicing events to control RBP expression levels and in turn alter their respective splicing networks.
ORGANISM(S): Mus musculus
PROVIDER: GSE54794 | GEO | 2014/03/17
SECONDARY ACCESSION(S): PRJNA237658
REPOSITORIES: GEO
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