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Long non-coding RNAs and mRNAs regulated by TGF-β

ABSTRACT: The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB promotes the invasion-metastasis cascade, which suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for anti-metastatic therapies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE54797 | GEO | 2014/02/08

SECONDARY ACCESSION(S): PRJNA237665

REPOSITORIES: GEO

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