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Genome-wide characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice

ABSTRACT: We sought to develop and characterize a novel paucibacillary model in mice, which develop necrotic lung granulomas following infection with Mycobacterium tuberculosis. Paucibacillary infection was established, recapitulating the sterilizing activities of human LTBI regimens. TNF neutralization led to increased lung bacillary load, disrupted granuloma architecture with expanded necrotic foci and reduced tissue hypoxia, and accelerated animal mortality. TNF-neutralized mouse lungs and sera showed significant upregulation of IFNγ, IL-1β, IL-6, IL-10, CCL2, CCL3, and matrix metalloproteinase genes

ORGANISM(S): Mus musculus

PROVIDER: GSE55183 | GEO | 2014/02/20

SECONDARY ACCESSION(S): PRJNA238823

REPOSITORIES: GEO

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Genome-wide characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice

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