Transcriptomics

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Coordinating Expression of RNA Binding Proteins with Their mRNA Targets


ABSTRACT: Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their target mRNAs in yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend to dampen expression variation among their target mRNAs. We further examined a well-studied RBP gene, PUF3, and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay. Our results provided new insights into the functional importance of RBPs in coordinating their target genes expression.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE55419 | GEO | 2014/06/01

SECONDARY ACCESSION(S): PRJNA239549

REPOSITORIES: GEO

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