Genomics

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Role of Polycomb group proteins in the DNA damage response – a reassessment


ABSTRACT: We have investigated whether components of Polycomb repressive complex 1 (PRC1) are recruited to double-strand breaks (DSBs) generated by inducible expression of the AsiSI restriction enzyme in normal human fibroblasts. Using chromatin immunoprecipitation and deep sequencing (ChIP-seq), which detects PRC1 proteins at common sites throughout the genome, we did not find evidence for recruitment of PRC1 components to AsiSI-induced DSBs. In contrast, the S2056 phosphorylated form of DNA-PKcs and other DNA repair proteins were detected at a subset of AsiSI sites that are predominantly at the 5’ ends of transcriptionally active genes. Our data question the idea that PcG protein recruitment provides a link between DSB repairs and transcriptional repression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE55605 | GEO | 2014/07/06

SECONDARY ACCESSION(S): PRJNA240224

REPOSITORIES: GEO

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