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Genes affected by SFRP5 overexpression in LSK cells and CLP

ABSTRACT: To understand gene expression signatures between wild-type and SFRP5-overexpressing cells

ORGANISM(S): Mus musculus

PROVIDER: GSE55646 | GEO | 2014/03/20

SECONDARY ACCESSION(S): PRJNA240285

REPOSITORIES: GEO

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Genes affected by SFRP5 overexpression in LSK cells and CLP

Project description:To understand gene expression signatures between wild-type and SFRP5-overexpressing cells To examine genes regulated by SFRP5 expression, sets of microarrays were conducted with Lin- c-kitHi Sca-1+ cells and Lin- c-kitLo Sca-1Lo IL7RÎ±+ CLP-enriched cells derived from adult bone marrow of SFRP5-transgenic mice or their WT littermates.

2014-03-20 | E-GEOD-55646 | biostudies-arrayexpress

Genes affected by Satb1 deficiency in HSC, LMPP and CLP

Project description:To understand gene expression signatures between wild-type and Satb1-deficient cells

2013-03-20 | GSE45299 | GEO

Genes affected by Satb1 deficiency in HSC, LMPP and CLP

Project description:To understand gene expression signatures between wild-type and Satb1-deficient cells To examine genes regulated by Satb1 expression, sets of microarrays were conducted with Lin- c-kitHi Sca-1+ Flt3- HSC-enriched cells, Lin- c-kitHi Sca-1+ Flt3+LMPP-enriched cells, and Lin- c-kitLo Sca-1Lo IL7RÎ±+ CLP-enriched cells derived from E18.5 FL of Satb1-null mice or their WT littermates.

2013-03-20 | E-GEOD-45299 | biostudies-arrayexpress

The presence and distribution of various genes in postnatal CLP-affected palatine tissue.

Project description:BackgroundWorldwide cleft lip with or without a cleft palate (CL/P) is the most common craniofacial birth defect. Apart from changes in facial appearance, additionally affected individuals often suffer from various associated comorbidities requiring complex multidisciplinary treatment with overall high expenses. Understanding the complete pathogenetic mechanisms of CL/P might aid in developing new preventative strategies and therapeutic approaches, help with genetic counselling, and improve quality of life. Many genes have been associated with the development of orofacial clefts; however, the majority require further research. Based on the role of PAX7, PAX9, SHH, SOX3, WNT3A, and WNT9B in orofacial development, the intention was to use chromogenic in situ hybridization to detect the six genes in postnatal CLP-affected palatine tissue and compare their distribution within the tissue samples.ResultsStatistically significant differences in the distribution of PAX7, PAX9, WNT3A, and WNT9B were observed. In total, 19 pairs of moderate to very strong positive correlations were noted.ConclusionsChanges in the cleft-affected palatine epithelium primarily seem to be associated with the PAX7 gene; however, PAX9, WNT3A, WNT9B, and SOX3 role seems to be more limited. Whilst connective tissue changes seem to depend on PAX7 only, SHH seems to participate individually and indistinctly. Numerous positive correlations reflect the complicating interactions of the pathways and their components in the orofacial cleft morphopathogenesis.

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DEK1 calpain overexpression

Project description:Aim: To understand the role of DEK1 in Arabidopsis development. Background: DEK1 has an essential role during embryogenesis and is involved in the maintenance of the epidermis. Tissues: Comparison of wild-type and ADEK1 calpain-overexpressing line.

2009-12-10 | GSE19268 | GEO

Genes affected by PAD4 deficiency in LSK cells obtained from mouse bone marrow.

Project description:We found PAD4, which is one of the transcriptional co-regulator by histone modification, was highly expressed in lineage-, Sca-1+, c-kit+ (termed as LSK) cells of mouse bone marrow. To find the target genes which are regulated by PAD4 in LSK cells, we analyzed gene expression in PAD4-deficient mouse as compared with wild-type mouse.

2013-06-01 | GSE45482 | GEO

DEK1 calpain overexpression

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Genes Express in Catalase Overexpression MAECs

Project description:Study the global genes expression in mouse aorta endothelial cells (MAECs) overexpressing human catalase (hcatTg). The wild type and overexpressing human catalase (hcatTg) MAECs grown to 80% confluence in six-well plates were made quiescent in serum-free DMEM for 12 h and then cultured in 10% FBS DMEM for 12 h. Total RNA was extracted with Trizol® reagent and purified by Rneasy Mini kit. Two independent wild type and two hcatTg total RNA samples were performed microarray with GeneChip® Mouse gene 1.0 ST array (Affymetrix, USA).

2011-03-08 | E-GEOD-27701 | biostudies-arrayexpress

Genes affected by PAD4 deficiency in LSK cells obtained from mouse bone marrow.

2013-06-01 | E-GEOD-45482 | biostudies-arrayexpress

Overexpression of subtilate4.13

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