Transcriptomics

Dataset Information

0

Taf7l Modulates Brown Adipose Tissue Formation


ABSTRACT: Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (Ucp1). Previously, we reported that the TATA-binding protein Associated Factor 7L (Taf7l) is an important regulator of white adipose tissue (WAT) differentiation. Here, we show that Taf7l also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, Taf7l containing TFIID complexes associate with PPAR to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that presence of the tissue-specific Taf7l subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification.

ORGANISM(S): Mus musculus

PROVIDER: GSE55797 | GEO | 2014/06/03

SECONDARY ACCESSION(S): PRJNA241016

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-06-03 | E-GEOD-55797 | biostudies-arrayexpress
2021-07-01 | GSE176453 | GEO
2017-10-28 | E-MTAB-4085 | biostudies-arrayexpress
2018-07-12 | PXD009262 | Pride
2013-01-07 | GSE41937 | GEO
2015-06-15 | E-GEOD-68544 | biostudies-arrayexpress
2013-01-07 | E-GEOD-41937 | biostudies-arrayexpress
2007-08-09 | GSE5510 | GEO
2020-02-07 | GSE144061 | GEO
2023-08-01 | GSE210613 | GEO