MeDIP chip from ZOS and ZOSM osteosarcoma cell lines
Ontology highlight
ABSTRACT: Epigenetic change of genes expression, including hypomethylation-linked activation of oncogenes and hypermethylation-associated inactivation of tumor suppressor genes, can affect almost all the cellular signaling pathways that participate in cancer initiation and progression. Unlike genetic alterations, epigenetic changes are potentially reversible, making them attractive and promising targets for therapeutic intervention. Studies indicated that abnormal DNA methylation is involved in dysregulation of cell cycle, apoptosis, proliferation and differentiation of osteosarcoma. However, epigenetic mechanisms of osteosarcoma metastasis remain largely unknown.
ORGANISM(S): Homo sapiens
PROVIDER: GSE55961 | GEO | 2015/08/25
SECONDARY ACCESSION(S): PRJNA241440
REPOSITORIES: GEO
ACCESS DATA