Global transcriptome profile of S aureus treated with celecoxib and ampicillin in combination
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ABSTRACT: We have previously shown that celecoxib, a selective COX-2 inhibitor, in combination with antibiotic sensitizes S aureus to antibiotic thereby decreasing the MIC of antibiotic. The present study is aimed at understanding the molecular mechanism of action of celecoxib on S aureus growth by microarray analysis. The results were analysed and the data clearly shows global change in the expression levels of S aureus genes in presence of celecoxib. Many virulence genes, essential genes and nonessential genes are down-regulated in presence of celecoxib in combination with ampicillin when compared to drug treatment alone.
ORGANISM(S): Staphylococcus aureus
PROVIDER: GSE56100 | GEO | 2015/06/02
SECONDARY ACCESSION(S): PRJNA242412
REPOSITORIES: GEO
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