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E2F1 transcription factor knockdown effect on gene expression in LNCaP-abl cells

ABSTRACT: Our computational approach identified E2F1 as a potential collaborator of EZH2 in androgen-independent prostate cancer. This experiment is to designed to validate the crosstalking of E2F1 and EZH2 pathways. We showed that majority of the EZH2-induced genes in androgen-independent prostate tumor cells are in downstream of E2F1, providing insight into the EZH2-E2F1 collaborative regulatory pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE56331 | GEO | 2016/01/22

SECONDARY ACCESSION(S): PRJNA242934

REPOSITORIES: GEO

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