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Molecular targets affected in the human whole-genome expression by Coriandrum sativum L. essential oil

ABSTRACT: Analysis of the effect of C. sativum (coriander) essential oil on the human genome with toxicological purposes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE56431 | GEO | 2014/04/03

SECONDARY ACCESSION(S): PRJNA243352

REPOSITORIES: GEO

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Molecular targets affected in the human whole-genome expression by Coriandrum sativum L. essential oil

Project description:Analysis of the effect of C. sativum (coriander) essential oil on the human genome with toxicological purposes. Total RNA was obtained from Hela Cells (CCL-2) treated with the essential oil at IC30 (inhibition concentration).

2014-04-03 | E-GEOD-56431 | biostudies-arrayexpress

Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression.

Project description:Oral candidiasis is an opportunistic fungal infection of the oral cavity with increasingly worldwide prevalence and incidence rates. Novel specifically-targeted strategies to manage this ailment have been proposed using essential oils (EO) known to have antifungal properties. In this study, we aim to investigate the antifungal activity and mode of action of the EO from Coriandrum sativum L. (coriander) leaves on Candida spp. In addition, we detected the molecular targets affected in whole-genome expression in human cells. The EO phytochemical profile indicates monoterpenes and sesquiterpenes as major components, which are likely to negatively impact the viability of yeast cells. There seems to be a synergistic activity of the EO chemical compounds as their isolation into fractions led to a decreased antimicrobial effect. C. sativum EO may bind to membrane ergosterol, increasing ionic permeability and causing membrane damage leading to cell death, but it does not act on cell wall biosynthesis-related pathways. This mode of action is illustrated by photomicrographs showing disruption in biofilm integrity caused by the EO at varied concentrations. The EO also inhibited Candida biofilm adherence to a polystyrene substrate at low concentrations, and decreased the proteolytic activity of Candida albicans at minimum inhibitory concentration. Finally, the EO and its selected active fraction had low cytotoxicity on human cells, with putative mechanisms affecting gene expression in pathways involving chemokines and MAP-kinase (proliferation/apoptosis), as well as adhesion proteins. These findings highlight the potential antifungal activity of the EO from C. sativum leaves and suggest avenues for future translational toxicological research.

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Project description:This series analyses germinating Lepidium sativum seeds with both temporal and spatial detail. This is a cross species microarray normalisation on Arabidopsis thaliana chips. Performed as part of the vSEED project

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Project description:In order to explore the bacteriostatic mechanism of Neolamarckia cadamba essential oil, the effect of Neolamarckia cadamba essential oil on microbial transcription in logarithmic growth phase was determined.

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