Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Wild type and ATG5-KO mouse dendritic cells exposed to interleukin-4 (IL4) and/or lipopolisaccharyde (LPS)

ABSTRACT: Male C57BL/6 normal and ATG5-KO mouse dendritic cells exposed to interleukin-4 (IL4) and/or lipopolisaccharyde (LPS)

ORGANISM(S): Mus musculus

PROVIDER: GSE56929 | GEO | 2015/06/16

SECONDARY ACCESSION(S): PRJNA244977

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Wild type and ATG5-KO mouse dendritic cells exposed to interleukin-4 (IL4) and/or lipopolisaccharyde (LPS)

Project description:Male C57BL/6 normal and ATG5-KO mouse dendritic cells exposed to interleukin-4 (IL4) and/or lipopolisaccharyde (LPS) 24 samples representing the different biological combinations between wild type and ko cells exposed to IL4 and LPS (three replicates for each)

2015-06-16 | E-GEOD-56929 | biostudies-arrayexpress

Il4

Project description:Rattus norvegicus Il4, interleukin 4 [Source:RGD Symbol;Acc:2898], is differentially expressed in 10 experiment(s);

| ENSRNOG00000007624 | ExpressionAtlas

Il4

Project description:Rattus norvegicus Il4, interleukin 4 [Source:RGD Symbol;Acc:2898], is expressed in 1 baseline experiment(s);

| ENSRNOG00000007624 | ExpressionAtlas

VAMP7 KO and ATG5 KO in axonal growth

Project description:VAMP7 is involved in autophagy and in exocytosis mediating neurite growth, two yet unconnected cellular pathways. Here we found that nutrient restriction and activation of autophagy stimulated axonal growth while inhibition led to multiple axons. VAMP7 KO neuronal cells showed impaired whereas ATG5 KO cells showed increased neurite growth. Secretomics identified that ER-phagy-related LC3 interacting region-containing proteins Atlastins and Reticulons were more abundant in ATG5 KO and less abundant in VAMP7 KO secretomes. The secretion of reticulon 3, LC3-II and P62 was impaired in VAMP7 KO cells. Treatment of neuronal cells with ATG5 or VAMP7 KO conditioned medium showed no effect thus the role of ATG5 and VAMP7 in neurite growth was cell autonomous. A nanobody directed against VAMP7 inhibited axonal growth induced by nutrient restriction. Furthermore, expression of the inhibitory Longin domain of VAMP7 impaired the subcellular localization of reticulon 3 in neurons. We propose that VAMP7-dependent unconventional autophagy-dependent secretion is an essential mechanism for axonal growth.

2021-03-29 | PXD020502 | Pride

IL4

Project description:Macaca mulatta IL4, interleukin 4 [Source:VGNC Symbol;Acc:VGNC:73729], is expressed in 2 baseline experiment(s);

| ENSMMUG00000003133 | ExpressionAtlas

IL4

Project description:Homo sapiens IL4, interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014], is differentially expressed in 36 experiment(s);

| ENSG00000113520 | ExpressionAtlas

Il4

Project description:Mus musculus Il4, interleukin 4 [Source:MGI Symbol;Acc:MGI:96556], is differentially expressed in 53 experiment(s);

| ENSMUSG00000000869 | ExpressionAtlas

IL4

Project description:Homo sapiens IL4, interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014], is expressed in 23 baseline experiment(s);

| ENSG00000113520 | ExpressionAtlas

Il4

Project description:Mus musculus Il4, interleukin 4 [Source:MGI Symbol;Acc:MGI:96556], is expressed in 30 baseline experiment(s);

| ENSMUSG00000000869 | ExpressionAtlas

IL4

Project description:Chlorocebus sabaeus IL4, interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014], is expressed in 1 baseline experiment(s);

| ENSCSAG00000013765 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data