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Effect of TLR Ligation on the Differentiation and Function of Human mMDSC

ABSTRACT: Immunosuppressive microenvironments block the activity of tumoricidal T and NK cells, allowing cancers to avoid immune elimination. Monocytic myeloid-derived suppressor cells (mMDSC) are an important component of these immunosuppressive milieus. Human mMDSC respond to stimulation via their Toll-like receptors by differentiating into macrophage. Agonists targeting TLRs 1/2 (such as PAM3) induce mMDSC to mature into immumosuppressive M2-like macrophage through a process that involves TNF and IL6. Agonists targeting TLRs 7/8 (such as R848) cause the same precursors to mature into tumoricidal M1-like macrophages, a process in which IL12 plays a central role. The immune suppression mediated by mMDSC is reversed by exposure to TLR 7/8 agonists which thus might be useful adjuncts for tumor immunotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57032 | GEO | 2014/07/21

SECONDARY ACCESSION(S): PRJNA245239

REPOSITORIES: GEO

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Effect of TLR Ligation on the Differentiation and Function of Human mMDSC

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