Nfatc1 enhances stem cell contribution to squamous skin tumors
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ABSTRACT: We find that epithelial-specific deletion of Nfatc1 decreases skin tumor susceptibility in mice subjected to DMBA/TPA carcinogenesis. To probe the molecular mechanisms by which Nfatc1 may regulate tumorigenesis, we identify gene expression changes associated with constitutive NFATc1 activation in primary mouse keratinocytes. Constitutively active NFATc1 activity in primary mouse keratinocytes to investigate how Nfatc1 regulates tumor initiation in the skin.
ORGANISM(S): Mus musculus
PROVIDER: GSE57314 | GEO | 2014/05/06
SECONDARY ACCESSION(S): PRJNA246233
REPOSITORIES: GEO
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